Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation.Therefore, disruption of signaling pathways involving these proteins has been linked to a range of diseases, including cancer.However, targeting individual cytokines, chemokines, or their receptors is challenging due to their regulatory redundancy and incomplete understanding of their signaling networks.To transform these difficult-to-drug targets into a pharmacologically manageable Board Game fisher price class, we developed a web-based platform called KinCytE.
This platform was designed to link the effects of kinase inhibitors, a well-established class of drugs, with cytokine and chemokine release and signaling networks.The resulting KinCytE platform enables users to investigate protein kinases that regulate specific cytokines or chemokines, generate a ranked list of FDA-approved kinase inhibitors that affect Household Products cytokine/chemokine activity, and explore and visualize cytokine signaling network thus facilitating drugging this challenging target class.KinCytE is freely accessible via https://atlas.fredhutch.
org/kincyte.